abstract：BACKGROUND:The t(12;21)(p13;q22) translocation is found in 20 to 25% of cases of childhood B-lineage acute lymphoblastic leukemia (B-ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very late relapse. TEL/AM...

journal_title：BMC genomics

authors： Gandemer V,Rio AG,de Tayrac M,Sibut V,Mottier S,Ly Sunnaram B,Henry C,Monnier A,Berthou C,Le Gall E,Le Treut A,Schmitt C,Le Gall JY,Mosser J,Galibert MD

更新日期：2007-10-23 00:00:00

abstract：BACKGROUND:Oil palm is the second largest source of edible oil which contributes to approximately 20% of the world's production of oils and fats. In order to understand the molecular biology involved in in vitro propagation, flowering, efficient utilization of nitrogen sources and root diseases, we have initiated an ex...

journal_title：BMC genomics

authors： Ho CL,Kwan YY,Choi MC,Tee SS,Ng WH,Lim KA,Lee YP,Ooi SE,Lee WW,Tee JM,Tan SH,Kulaveerasingam H,Alwee SS,Abdullah MO

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:The measurement of gene expression using microarray technology is a complicated process in which a large number of factors can be varied. Due to the lack of standard calibration samples such as are used in traditional chemical analysis it may be a problem to evaluate whether changes done to the microarray pr...

journal_title：BMC genomics

authors： Bruland T,Anderssen E,Doseth B,Bergum H,Beisvag V,Laegreid A

更新日期：2007-10-18 00:00:00

abstract：UNLABELLED:Little is known, either experimentally or computationally, about the genomic sequence features that regulate malaria genes. A sequence conservation analysis of the malaria species P. falciparum, P. berghei, P. yoelii, and P. chabaudi could significantly advance knowledge of malaria gene regulation. RESULTS:...

journal_title：BMC genomics

authors： Imamura H,Persampieri JH,Chuang JH

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:Many bacterial chromosomes display nucleotide asymmetry, or skew, between the leading and lagging strands of replication. Mutational differences between these strands result in an overall pattern of skew that is centered about the origin of replication. Such a pattern could also arise from selection coupled ...

journal_title：BMC genomics

authors： Morton RA,Morton BR

更新日期：2007-10-12 00:00:00

abstract：UNLABELLED:Transcription-induced chimerism, a mechanism involving the transcription and intergenic splicing of two consecutive genes, has recently been estimated to account for approximately 5% of the human transcriptome. Despite this prevalence, the regulation and function of these fused transcripts remains largely un...

journal_title：BMC genomics

authors： Wang K,Ubriaco G,Sutherland LC

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:We performed large-scale bacterial artificial chromosome (BAC) end-sequencing of two BAC libraries (an EcoRI- and a BamHI-digested library) and conducted an in silico analysis to characterize the obtained sequence data, to make them a useful resource for genomic research on the silkworm (Bombyx mori). RESUL...

journal_title：BMC genomics

authors： Suetsugu Y,Minami H,Shimomura M,Sasanuma S,Narukawa J,Mita K,Yamamoto K

更新日期：2007-09-07 00:00:00

abstract：BACKGROUND:Thymoma is a heterogeneous group of tumors in biology and clinical behavior. Even though thymoma is divided into five subgroups following the World Health Organization classification, the nature of the disease is mixed within the subgroups. RESULTS:We investigated the molecular characteristics of genetic ch...

journal_title：BMC genomics

authors： Lee GY,Yang WI,Jeung HC,Kim SC,Seo MY,Park CH,Chung HC,Rha SY

更新日期：2007-09-03 00:00:00

abstract：BACKGROUND:Fluctuations in external salinity force eukaryotic cells to respond by changes in the gene expression of proteins acting in protective biochemical processes, thus counteracting the changing osmotic pressure. The high-osmolarity glycerol (HOG) signaling pathway is essential for the efficient up-regulation of ...

journal_title：BMC genomics

authors： Vaupotic T,Plemenitas A

更新日期：2007-08-16 00:00:00

abstract：BACKGROUND:Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. This stu...

journal_title：BMC genomics

authors： Ferrari F,Bortoluzzi S,Coppe A,Basso D,Bicciato S,Zini R,Gemelli C,Danieli GA,Ferrari S

更新日期：2007-08-03 00:00:00

abstract：BACKGROUND:The completion of the Plasmodium falciparum genome represents a milestone in malaria research. The genome sequence allows for the development of genome-wide approaches such as microarray and proteomics that will greatly facilitate our understanding of the parasite biology and accelerate new drug and vaccine ...

journal_title：BMC genomics

authors： Lu F,Jiang H,Ding J,Mu J,Valenzuela JG,Ribeiro JM,Su XZ

更新日期：2007-07-27 00:00:00

abstract：BACKGROUND:The out of Africa hypothesis has gained generalized consensus. However, many specific questions remain unsettled. To know whether the two M and N macrohaplogroups that colonized Eurasia were already present in Africa before the exit is puzzling. It has been proposed that the east African clade M1 supports a ...

journal_title：BMC genomics

authors： González AM,Larruga JM,Abu-Amero KK,Shi Y,Pestano J,Cabrera VM

更新日期：2007-07-09 00:00:00

abstract：BACKGROUND:Genetic influences underpinning complex traits are thought to involve multiple quantitative trait loci (QTLs) of small effect size. Detection of such QTL associations requires systematic screening of large numbers of DNA markers within large sample populations. Using pooled DNA on SNP microarrays to screen f...

journal_title：BMC genomics

authors： Docherty SJ,Butcher LM,Schalkwyk LC,Plomin R

更新日期：2007-07-04 00:00:00

abstract：BACKGROUND:The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal mode...

journal_title：BMC genomics

authors： Datson NA,Morsink MC,Atanasova S,Armstrong VW,Zischler H,Schlumbohm C,Dutilh BE,Huynen MA,Waegele B,Ruepp A,de Kloet ER,Fuchs E

更新日期：2007-06-25 00:00:00

abstract：BACKGROUND:Microarray gene expression (MAGE) signatures allow insights into the transcriptional processes of leukemias and may evolve as a molecular diagnostic test. Introduction of MAGE into clinical practice of leukemia diagnosis will require comprehensive assessment of variation due to the methodologies. Here we sys...

journal_title：BMC genomics

authors： Campo Dell'Orto M,Zangrando A,Trentin L,Li R,Liu WM,te Kronnie G,Basso G,Kohlmann A

更新日期：2007-06-22 00:00:00

abstract：BACKGROUND:Plants respond to low temperature through an intricately coordinated transcriptional network. The CBF/DREB-regulated network of genes has been shown to play a prominent role in freeze-tolerance of Arabidopsis through the process of cold acclimation (CA). Recent evidence also showed that the CBF/DREB regulon ...

journal_title：BMC genomics

authors： Cheng C,Yun KY,Ressom HW,Mohanty B,Bajic VB,Jia Y,Yun SJ,de los Reyes BG

更新日期：2007-06-18 00:00:00

abstract：BACKGROUND:Microsatellites (repeated subsequences based on motifs of one to six nucleotides) are widely used as codominant genetic markers because of their frequent polymorphism and relative selective neutrality. Minisatellites are repeats of motifs having seven or more nucleotides. The large number of EST sequences no...

journal_title：BMC genomics

authors： Crane CF

更新日期：2007-06-15 00:00:00

abstract：BACKGROUND:DNA microarrays provide the ability to interrogate multiple genes in a single experiment and have revolutionized genomic research. However, the microarray technology suffers from various forms of biases and relatively low reproducibility. A particular source of false data has been described, in which non-ran...

journal_title：BMC genomics

authors： Koren A,Tirosh I,Barkai N

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:Descriptive hierarchical Poisson models and population-genetic coalescent mixture models are used to describe the observed variation in single-nucleotide polymorphism (SNP) density from samples of size two across the human genome. RESULTS:Using empirical estimates of recombination rate across the human geno...

journal_title：BMC genomics

authors： Sainudiin R,Clark AG,Durrett RT

更新日期：2007-06-06 00:00:00

abstract：BACKGROUND:The development of microarrays permits us to monitor transcriptomes on a genome-wide scale. To validate microarray measurements, quantitative-real time-reverse transcription PCR (Q-RT-PCR) is one of the most robust and commonly used approaches. The new challenge in gene quantification analysis is how to expl...

journal_title：BMC genomics

authors： Su LJ,Chang CW,Wu YC,Chen KC,Lin CJ,Liang SC,Lin CH,Whang-Peng J,Hsu SL,Chen CH,Huang CY

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Previous studies of individual genes have shown that in a self-enforcing way, dimethylation at histone 3 lysine 9 (dimethyl-H3K9) and DNA methylation cooperate to maintain a repressive mode of inactive genes. Less clear is whether this cooperation is generalized in mammalian genomes, such as mouse genome. He...

journal_title：BMC genomics

authors： Wu J,Wang SH,Potter D,Liu JC,Smith LT,Wu YZ,Huang TH,Plass C

更新日期：2007-05-24 00:00:00

abstract：BACKGROUND:Dictyostelium discoideum is frequently subjected to environmental changes in its natural habitat, the forest soil. In order to survive, the organism had to develop effective mechanisms to sense and respond to such changes. When cells are faced with a hypertonic environment a complex response is triggered. It...

journal_title：BMC genomics

authors： Na J,Tunggal B,Eichinger L

更新日期：2007-05-21 00:00:00

abstract：BACKGROUND:White spot syndrome (WSS) is a viral disease that affects most of the commercially important shrimps and causes serious economic losses to the shrimp farming industry worldwide. However, little information is available in terms of the molecular mechanisms of the host-virus interaction. In this study, we used...

journal_title：BMC genomics

authors： Leu JH,Chang CC,Wu JL,Hsu CW,Hirono I,Aoki T,Juan HF,Lo CF,Kou GH,Huang HC

更新日期：2007-05-16 00:00:00

abstract：BACKGROUND:Gene knockouts are a critical resource for functional genomics. In Arabidopsis, comprehensive knockout collections were generated by amplifying and sequencing genomic DNA flanking insertion mutants. These Flanking Sequence Tags (FSTs) map each mutant to a specific locus within the genome. In maize, FSTs have...

journal_title：BMC genomics

authors： Settles AM,Holding DR,Tan BC,Latshaw SP,Liu J,Suzuki M,Li L,O'Brien BA,Fajardo DS,Wroclawska E,Tseung CW,Lai J,Hunter CT 3rd,Avigne WT,Baier J,Messing J,Hannah LC,Koch KE,Becraft PW,Larkins BA,McCarty DR

更新日期：2007-05-09 00:00:00

abstract：BACKGROUND:Pfam is a general-purpose database of protein domain alignments and profile Hidden Markov Models (HMMs), which is very popular for the annotation of sequence data produced by genome sequencing projects. Pfam provides models that are often very general in terms of the taxa that they cover and it has previousl...

journal_title：BMC genomics

authors： Alam I,Hubbard SJ,Oliver SG,Rattray M

更新日期：2007-04-10 00:00:00

abstract：BACKGROUND:ATP binding cassette (ABC) systems are responsible for the import and export of a wide variety of molecules across cell membranes and comprise one of largest protein superfamilies found in prokarya, eukarya and archea. ABC systems play important roles in bacterial lifestyle, virulence and survival. In this s...

journal_title：BMC genomics

authors： Harland DN,Dassa E,Titball RW,Brown KA,Atkins HS

更新日期：2007-03-28 00:00:00

abstract：BACKGROUND:Cattle and other ruminants have evolved the ability to derive most of their metabolic energy requirement from otherwise indigestible plant matter through a symbiotic relationship with plant fibre degrading microbes within a specialised fermentation chamber, the rumen. The genetic changes underlying the evolu...

journal_title：BMC genomics

authors： Wheeler TT,Hood KA,Maqbool NJ,McEwan JC,Bingle CD,Zhao S

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:Myostatin, a muscle-specific member of the Transforming Growth Factor beta family, negatively regulates muscle development. Double-muscled (DM) cattle have a loss-of-function mutation in their myostatin gene responsible for the hypermuscular phenotype. Thus, these animals are a good model for understanding t...

journal_title：BMC genomics

authors： Cassar-Malek I,Passelaigue F,Bernard C,Léger J,Hocquette JF

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Rhesus macaques serve a critical role in the study of human biomedical research. While both Indian and Chinese rhesus macaques are commonly used, genetic differences between these two subspecies affect aspects of their behavior and physiology, including response to simian immunodeficiency virus (SIV) infecti...

journal_title：BMC genomics

authors： Ferguson B,Street SL,Wright H,Pearson C,Jia Y,Thompson SL,Allibone P,Dubay CJ,Spindel E,Norgren RB Jr

更新日期：2007-02-07 00:00:00

abstract：BACKGROUND:Pyrethroid resistance in Anopheles funestus populations has led to an increase in malaria transmission in southern Africa. Resistance has been attributed to elevated activities of cytochrome P450s but the molecular basis underlying this metabolic resistance is unknown. Microsatellite and SNP markers were use...

journal_title：BMC genomics

authors： Wondji CS,Morgan J,Coetzee M,Hunt RH,Steen K,Black WC 4th,Hemingway J,Ranson H

更新日期：2007-01-29 00:00:00

abstract：BACKGROUND:Despite the importance of chromosomal translocations in the initiation and/or progression of cancer, a comprehensive catalog of translocation breakpoints in which these are precisely located on the reference sequence of the human genome is not available at present. DESCRIPTION:We have created a database tha...

journal_title：BMC genomics

authors： Novo FJ,de Mendíbil IO,Vizmanos JL

更新日期：2007-01-26 00:00:00

abstract：BACKGROUND:Regulatory networks often employ the model that attributes changes in gene expression levels, as observed across different cellular conditions, to changes in the activity of transcription factors (TFs). Although the actual conditions that trigger a change in TF activity should form an integral part of the ge...

journal_title：BMC genomics

authors： Knijnenburg TA,de Winde JH,Daran JM,Daran-Lapujade P,Pronk JT,Reinders MJ,Wessels LF

更新日期：2007-01-22 00:00:00

abstract：BACKGROUND:Nuclear receptors are hormone-regulated transcription factors whose signaling controls numerous aspects of development and physiology. Many receptors recognize DNA hormone response elements formed by direct repeats of RGKTCA motifs separated by 1 to 5 bp (DR1-DR5). Although many known such response elements ...

journal_title：BMC genomics

authors： Laperriere D,Wang TT,White JH,Mader S

更新日期：2007-01-19 00:00:00

abstract：BACKGROUND:The programmed cell death 2 (Pdcd2) gene on mouse chromosome 17 was evaluated as a member of a highly conserved synteny, a candidate for an imprinted locus, and a candidate for the Hybrid sterility 1 (Hst1) gene. RESULTS:New mouse transcripts were identified at this locus: an alternative Pdcd2 mRNA skipping...

journal_title：BMC genomics

authors： Mihola O,Forejt J,Trachtulec Z

更新日期：2007-01-18 00:00:00

abstract：BACKGROUND:The establishment of C4 photosynthesis in maize is associated with differential accumulation of gene transcripts and proteins between bundle sheath and mesophyll photosynthetic cell types. We have physically separated photosynthetic cell types in the leaf blade to characterize differences in gene expression ...

journal_title：BMC genomics

authors： Sawers RJ,Liu P,Anufrikova K,Hwang JT,Brutnell TP

更新日期：2007-01-09 00:00:00

abstract：BACKGROUND:Microsatellites are extremely common in plant genomes, and in particular, they are significantly enriched in the 5' noncoding regions. Although some 5' noncoding microsatellites involved in gene regulation have been described, the general properties of microsatellites as regulatory elements are still unknown...

journal_title：BMC genomics

authors： Zhang L,Zuo K,Zhang F,Cao Y,Wang J,Zhang Y,Sun X,Tang K

更新日期：2006-12-25 00:00:00

abstract：BACKGROUND:The pattern of point mutation is important for studying mutational mechanisms, genome evolution, and diseases. Previous studies of mutation direction were largely based on substitution data from a limited number of loci. To date, there is no genome-wide analysis of mutation direction or methylation-dependent...

journal_title：BMC genomics

authors： Jiang C,Zhao Z

更新日期：2006-12-13 00:00:00

abstract：BACKGROUND:Rice blast, caused by the fungal pathogen Magnaporthe grisea, is a devastating disease causing tremendous yield loss in rice production. The public availability of the complete genome sequence of M. grisea provides ample opportunities to understand the molecular mechanism of its pathogenesis on rice plants a...

journal_title：BMC genomics

authors： Gowda M,Venu RC,Raghupathy MB,Nobuta K,Li H,Wing R,Stahlberg E,Couglan S,Haudenschild CD,Dean R,Nahm BH,Meyers BC,Wang GL

更新日期：2006-12-08 00:00:00

abstract：BACKGROUND:The giant panda, one of the most primitive carnivores, is an endangered animal. Although it has been the subject of many interesting studies during recent years, little is known about its genome. In order to promote research on this genome, a bacterial artificial chromosome (BAC) library of the giant panda w...

journal_title：BMC genomics

authors： Liu W,Zhao Y,Liu Z,Zhang Y,Lian Z,Li N

更新日期：2006-11-17 00:00:00

abstract：BACKGROUND:Increased focus surrounds identifying patients with advanced non-small cell lung cancer (NSCLC) who will benefit from treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI). EGFR mutation, gene copy number, coexpression of ErbB proteins and ligands, and epithelial to mesenchy...

journal_title：BMC genomics

authors： Balko JM,Potti A,Saunders C,Stromberg A,Haura EB,Black EP

更新日期：2006-11-10 00:00:00